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Anti-psychotic drugs, such as clozapine, were not introduced clinically until the s. Janet Sternburg wrote the book White Matter: A Memoir of Family and Medicine , after learning that two of her aunts had frontal lobotomies. One suffered from depression while the other was schizophrenic. Sternburg wrote, "There was no real alternative to locking psychotic patients up; there were no anti-psychotic drugs yet. Mental illness was a stigma that made families try to hide the existence of their mentally ill members and made potential spouses hesitant to marry into a tainted family.

That attitude probably made it more acceptable to experiment on patients. Portuguese neurologist Antonia Moniz performed the first lobotomy in , drilling holes into a patient's skull, pouring alcohol into the frontal cortex to sever the nerves, before coring sections of the brain with hollow needles. This procedure, which he called a "leucotomy", was supposed to cure a variety of mental health issues, particularly depression and schizophrenia, for patients who were believed to be beyond help. Today, we know that his method was barbaric and the fact that he wasn't a doctor should have sent shudders down the spines of anybody in contact with him. Yet, in , Moniz received a Nobel Prize for his work.

There have been widespread calls for his prize to be revoked but nothing has been done about it yet. The theory that mental health could be improved by psychosurgery first came from Swiss neurologist Gottlieb Burckhardt, who claimed he had a 50 per cent success rate when he operated on schizophrenics. Even though his colleagues criticised his work, Burckhardt claimed that, following the operation, the patients appeared to calm down. This "calmness" was more likely due to the patients being in a "zombie-like" or vegetative state, unable to speak or think for themselves. US neuropsychiatrist Walter Freeman was intrigued with Moniz's work and decided to experiment for himself.

Freeman believed that mental illness was caused by overactive emotions, and if the brain was cut up, he'd be effectively cutting away those emotions. After practising for a few weeks on cadavers, Freeman performed the first frontal lobotomy in the US, on year-old Alice Hood Hammatt, a housewife from Kansas who was believed to be suffering from anxiety and depression. Assisted by Dr James Watt, Freeman drilled holes in Hammatt's skull over the left and right frontal lobes.

They then inserted a leucotome a narrow shaft through the hole on the left side into the exposed part of the brain. An hour later, Freeman declared the operation was a success, even though Hammatt suffered a convulsion in the weeks following the surgery. Hammatt died five years after her surgery, although she managed to spend the last years of her life away from mental institutions.

This so-called success led Freeman to come up with a new plan. He wanted to devise a lobotomy that was faster and less messy than drilling holes into a person's skull. So he went back to experimenting on cadavers, searching for an easy way to access the brain. He used a tool he'd found in his kitchen — an ice pick. Freeman realised he could easily reach the brain by using the icepick, which was into the brain through the eye sockets; he named this radically invasive form of brain surgery a "transorbital lobotomy" but it became more commonly known as the "icepick lobotomy".

The barbaric procedure was responsible for at least deaths and left thousands of people in a vegetative state. Sadly, in many cases, that was believed to be an improvement in the lives of many mentally ill people as they were now easier for mental institutions or family members to take care of. He personally performed , travelling across the US, until complications and psychiatric meds eliminated the procedure. First, the patient was rendered unconscious by electroshock or simply given a local anaesthetic depending on their mental health. Then the icepick-like instrument was inserted above the patient's eyeball.

Using a hammer, the icepick was hammered into the eggshell thin bone above the eye, where the instrument was wriggled back and forth to sever the connections to the prefrontal cortex in the frontal lobes of the brain. It's difficult to believe that an icepick can be hammered into the most complex part of the human body — the brain — while the instrument was moved from side to side by a man who was not a surgeon.

The operation was over in around 10 minutes and in at least a third of all cases, rendered the patients compliant, docile and mute with childlike behaviour. Twelve-year-old Howard Dully was forced to have a lobotomy because, as his stepmother insisted, he was "defiant, daydreamed and even objected to going to bed". In other words, he was a typical year-old. He was taken to several doctors who all concluded that Howard was "just normal".

But his stepmother took him to Freeman who suggested the boy undergo a lobotomy. Freeman wrote in his diary about Howard in November: "I explained to Mrs Dully that the family should consider the possibility of changing Howard's personality by means of transorbital lobotomy. Mrs Dully said it was up to her husband, that I would have to talk with him and make it stick. December: "Mr and Mrs Dully have apparently decided to have Howard operated on. I suggested they not tell Howard anything about it. January 4, , following the year-old's lobotomy: "I told Howard what I'd done to him … and he took it without a quiver. He sits quietly, grinning most of the time and offering nothing. Howard told America's National Public Radio in , when he was 56, that he's always felt different and wondered if there was something missing from his soul.

According to medical historian Dr Lindsey Fitzharris, Rosemary was said to be a rebellious child who experienced the occasional mood swings. In November , her father took her to see Freeman who was, by then, famous. Freeman performed the operation right then and there on Rosemary, without her mother's knowledge," Dr Fitzharris said. Rosemary could no longer speak, and her mental capacity was equivalent to that of a toddler.

Rosemary never did recover her ability to speak coherently and remained in care until her death in at the age of

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